Ultra-processed foods, which are often high in sugar, salt, unhealthy fats, and other additives, have been strongly connected to obesity and metabolic disorders. Regularly eating these ultra-processed foods may disturb appetite regulation, increase calorie intake, and cause insulin resistance, dyslipidemia, and chronic inflammation. Many studies have linked ultra-processed foods to an increased risk of cardiovascular diseases, type 2 diabetes and other chronic diseased related to diet. Ultra-processed foods have low nutritional value and high energy density, which serves as a major obstacle toward healthy eating patterns and the health effects of ultra-processed foods are long-term. Consequently, it is important to reduce ultra-processed food consumption and, when possible, replace ultra-processed foods with whole, minimally processed foods for metabolic health, obesity prevention, and overall well-being.