MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression and are integral to the development of obesity and metabolic regulation. They regulate several biological processes, including adipogenesis, lipid metabolism, insulin signaling, and inflammation. Additionally, some miRNAs are specifically associated with white and brown fat cell differentiation, energy homeostasis, and complications of obesity. Hence, miRNAs can serve as biomarkers for obesity and related metabolic diseases. Furthermore, research investigating miRNA regulation highlights the potential of the miRNA biogenesis pathway as a therapeutic target, which will lead to the identification of novel strategies for addressing obesity and metabolic syndrome. Understanding microRNA regulation can improve our understanding of the molecular mechanism(s) associated with obesity and may enable the development of personalized interventions and therapies.
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