The gut virome, consisting of the diverse community of viruses residing in the gastrointestinal tract, is increasingly recognized as a key player in metabolic health. These viruses interact with gut bacteria, the immune system, and various aspects of host metabolism. Recent research indicates that the gut virome can influence energy homeostasis, fat storage, and insulin sensitivity—factors directly linked to obesity and metabolic disorders. Alterations in the composition of the gut virome have been associated with metabolic syndrome, type 2 diabetes, and obesity, underscoring its role in maintaining both intestinal and systemic balance.Understanding the complex interplay between gut viruses and other components of the microbiome offers new perspectives on microbiome-based therapies, personalized nutrition, and interventions aimed at improving metabolic health. By investigating the gut virome, researchers are uncovering crucial connections between diet, microorganisms, viruses, and host metabolic processes. These insights may pave the way for novel strategies to prevent and manage obesity and related metabolic diseases.
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