Genetically based personalized nutrition (nutrigenomics) is changing how we view the interplay between diet, genes, and health. By examining the naturally occurring variations in each individual’s genetic makeup (genotype) that influence nutrient metabolism, appetite regulation, and disease susceptibility, nutrigenomics provides a framework for tailoring dietary strategies to each person’s genetic profile. This new area of nutrition science goes beyond general recommendations and aims to optimize metabolic health, facilitate nutrient absorption, and decrease chronic disease risk (e.g., obesity, diabetes, cardiovascular disease). Personalized nutrition has emerged as an area of precision medicine driven by advances in genomic technologies and bioinformatics, while creating new avenues for preventive measures and health optimization.