Obesity has a significant impact on bone health and skeletal integrity. Excess weight, hormonal effects, and changes in metabolism may affect bone density and fracture risk. Evidence-based interventions for preserving bone strength—via optimal nutrition, goal-oriented physical activity, and lifestyle interventions—are crucial in the management of weight. Practical information for clinicians, researchers, and healthcare professionals to optimize musculoskeletal and metabolic health in persons with obesity can be found in this content.